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Cancer new therapy: penetrating blood brain barrier, cannabin or big effect

2022/03/28

Effective through the blood brain barrier, leading to apoptosis, cannabinoids, or a big effect in tumor cells.

Cancer is a common enemy of human beings, relieve cancer symptoms, or even overcoming cancer is our common goal, cannabin is just a hope of such desperation, why don't we try to try?

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Northern United University cancer new therapy: through blood brain barrier


The "National Academy of National Academy" published an online study of a stone to provoke thousands of waves, "New therapy can extend the survival rate of breast cancer, prevent recurrence, the treatment of three-negative breast cancer mice 150%. Researchers in Northwestern University (Northwestern University) have developed a new immunotherapy, which can significantly extend the survival time of mice with triple-negative breast cancer. Three-negative breast cancer is one of the most invasive and discrete treatment in breast cancer. In a new study, mice received this therapy were completely relieved at least 100 days. All untreated mice died on the 30th day. All of the treated mice did not have a poor side effects or autoimmune reactions. This kind of spherical nucleic acid (SNA) Nanoparticles are a sphere DNA can easily enter and stimulate immune cells. Chad A. Mirkin It is the Northwestern University Wenberg Arts Institute George B. Rathmann Professor of Chemistry, Director of International Nanotechnology, Northwestern University Robert H. Lurie Member of the integrated cancer center, leading this study and invented SNA of Chad The shape and structure of nanoparticles are attributed to the success of immunotherapy.


According to industry insiders, nanoherapy is a spherical nucleic acid (SNA) drug, with a unique 3D design, composed of nanoparticles surrounded by nucleic acids. The drug passes through a blood brain barrier, leading to tumor cell apoptosis. Glightean skeletarns are a fatal brain tumor that affects thousands of patients in the United States each year; this deadly brain cancer has no effective treatment. Preliminary clinical trials in patients with recurrent glioma skeletarns have shown that small doses are harmless to humans, and the drug does cross the blood brain barrier. A new type of drug using the SNA platform can be applied to other types of neurological diseases by passing through a blood-brain barrier and targeting tumor cells associated with these diseases, including Alzheimer's disease and Parkinson's disease.


Note: US Northwestern University official website news original link

Https://news.northwestern.edu/stories/2020/07/new-therapy-extends-breast-cancer-survival-rate-prevents-reoccurrence/



Through the blood brain barrier, leading to tumor cell apoptosis, cannabinoids or the role


This news suddenly pushed Northwestern University to the high point. People madly look for solutions to fight cancer, have there any way to break through the blood-brain barrier?


Yes, doctors will remind you, don't forget, break through blood brain barriers, cannabin, or a big role! In order to protect the brain, the human body constructs a blood-brain barrier to prevent harmful substances from entering brain tissue, protecting the central nervous system, but the problem is that a lot of drugs can't enter the brain. Since cannabinoids can pass the blood brain barrier, we can use it as a medium to develop new drugs for the treatment of brain disease by loading small molecules above. Therefore, June 26, 2018, FDA approved the world's first cannabis phenol drugs in the world's first cannteen to treat children's epilepsy, just opened industrial marijuana. For details, you can view the Securities Times Interview with Hanxia Group Tan Wei: China's pharmaceutical industry has historic opportunities!


Coincidentally, well-known enterprises in Cannabis Industry GW Pharmaceuticals ( GWPH ) The road that has been approved by the first marijuana derivative therapy in the United States. However, an early trial showed that these treatments may also be one of the most destructive brain cancer: the effective method of polymorrhagic skeletarns. This headquartered company published a medium-term study in 2017, which is about a combination of hemp phenol and THC Experimental drugs. The results so far suggest that the drug increases the median survival rate of patients with cerebral cancer compared to placebo for about six months. Typically, this type of cancer will destroy the brain, and (average) has made it within two years being diagnosed. 70% The patient died.


"We believe that the efficacy signals shown in these studies have further strengthened the potential role of cannabin in the field of oncology, and GW Provide a new, unique cannabin product candidate for the treatment of gelactoma prospects, "GW The CEO Justin Gover said in a statement.



How can marinee pass through a blood brain barrier, leading to tumor cell apoptosis?


In fact, in the treatment of cancer, the special effects of cannabinoids should be placed under the spotlight, and is remembered by the world. US "Immunization Biology" was published in August 2010 "Cannabin induced immune cell apoptosis as an immunosuppressive pathway", it has been reviewed in detail of cannabinoid treatment cancer.



Cannabin is a group of compounds present in cannabis sativa L., to regulate their physiological and behavioral effects by activating specific cannabin receptors. As the cannabin receptor (CB1 and CB2) and endogenous cannabinoid systems, the study of cannabinoids were expanded in an exponential level. Cannabin has been proven to be an effective immunosuppressive agent and anti-inflammatory agent, and has shown in various immune-mediated diseases (such as multiple sclerosis, diabetes, infectious shock, rheumatoid arthritis and allergic asthma) ) Intermediary guidance. Cannabin Receptor 1 (CB1) is mainly expressed in cells of the central nervous system and peripheral cells. In contrast, cannabin receptor 2 (CB2) is mainly expressed in immune cells. The exact mechanism of cannabinoid mediated immunosuppression is now just being understood, and can be roughly divided into four ways: cell apoptosis, proliferation inhibition, cytokine and chemokinetic factor, and T regulate cells (T REGS) Induction. This article focuses on natural and synthetic cannabinoids by activating CB2 receptor induced apoptosis, focusing on the apoptosis mechanism of cannabin-mediated immunosuppression on different immune cell populations, and discusses the activation of CB2 Inflammation and autoimmune diseases and immune systems provide a new treatment, without poor psychotropic effects.


For centuries, marijuana has been used for entertainment and medicinal purposes. Cannabinic has been proven to be effective in treating nausea and vomiting related to cancer chemotherapy, anorexia and evilness in patients with HIV / AIDS, and neuropathic pain and spasm in multiple sclerosis (Guzman 2003; InUI 2002; Pollmann and Fenenberg 2008). Recently, the anti-inflammatory characteristics of cannabinoid have caused great attention. In the past 15 years, the study of marijuana gainabase results in the discovery of cannabin receptors (CB1 and CB2) and its endogenous ligands, which constitute endogenous cannabin systems. CB1 and CB2 are all heterologous trimer gi / o protein coupled receptors. CB1 is expressed in the central nervous system (CNS) and peripheral tissues, mainly expressed in synaptic nerve. CB2, sometimes referred to as "peripheral cannabin receptor", which is mainly expressed in immune cells, but can also be found in other outer peripherals, such as retinal and central nervous systems (Croxford and Yamamura 2005; Mackie 2006). The endogenous cannabin system regulates many functions, such as sports, memory, appetite, body temperature regulation, pain, and immune function. Natural and synthetic cannabinases come from cannabis plants, and endogenous cannabinase is a metabolite of peanut tetrane (Klein and Cabral 2006). The picture summarizes some famous natural and synthetic cannabinoids, as well as their sources and receptors.

In addition, a group of researchers have studied the effects of non-psychoactive cannabin cannabis diphene (CBD) on immune cell apoptosis (Lee et al., 2008). They prove that CBD induces apoptosis in the CD4 + and CD8 + T cell populations. The splenocytes were treated with 4-8 μM CBD significantly increased apoptosis, which was determined by the percentage of subusiganoid cells and TUNEL positive cells. In addition, researchers have shown that apoptosis is due to the formation of activated oxygen (ROS), the activation of cystein 8 and cystein 3. The same group also reported that CBD has a similar effect on mouse thymocytes and EL-4 cells.

Natural and synthetic cannabinoids can induce T cell apoptosis. THC (20 μM) and JWH-015 (5, 10, 20 μm) were induced by connecting CB2 receptors to induce T cell apoptosis. JWH-015 activates the intrinsic pathway and an external pathway, THC is lowered by Bcl-2 mRNA and induces Caspase 1 activity. Currently unclear whether CBD and AJA play a role through receptor-dependent pathways; however, a report suggests that CBD may mediate its role through CB2 receptors (McKallip et al., 2006).


Amazing cancer data


Why do you want to have a big medicated cancer? Crawler a thrilling data for you to view:

Global cancer burden intensifies, Chinese cancer new cases and deaths in the world. According to the World Health Organization International Cancer Research Institute (IARC), the 2020 global new cancer burden data:


· At present, one-fifth of the world will have cancer in his life.

· 2020 Global diagnosed cancer patients reached 19.3 million, while the number of people died of cancer increased to 10 million.

· It is expected to increase by 50% compared to 2020 due to agricultural growth of population aging. At that time, the number of new new cancer cases will reach nearly 30 million. This is the most significant in countries that are experiencing social and economic transformation.

· Double double top: Chinese cancer new cases (4.57 million cases in 2020) and the number of deaths (3 million cases) the world's first.

· 7.5 people were diagnosed with cancer every minute, and China became a veritable "cancer country".


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