Researchers credit the widespread medical applications of marijuana to the endocannabinoid system (the natural cannabinoid system of your body.) What they found is that cannabinoid receptors are in many parts of your body, even your white blood cells. Because of this, researchers are continuing their promising investigation of marijuana for leukemia.
Leukemia & Medical Marijuana Research
A study from 2005 looked into the role of mitogen-activated protein kinases (MAPKs) in cannabinoid-induced leukemia cell death. Some types of MAPKs take part in apoptosis and autophagy, or cell death and turnover. Understanding how cannabis causes cancer cell death can help us learn how to make better treatments, so the researchers behind this study specifically examined the CB2 receptor.
Before observing the cell death process, the team reaffirmed that their leukemia cells had CB2 receptors. After confirming their presence, they administered THC and another CB2-related cannabinoid. A type of MAPK called p38 MAPK activated in response to CB2 receptor stimulation, showing a link. Blocking p38 MAPK lessened the CB2 receptor’s ability to kill leukemia cells.
Another study supported the possibility of using cannabis as a supplement to radiation therapy. When a team from Israel observed the effects of CBD and a synthetic counterpart on leukemia cells, they recorded the effects that occurred in cells with and without prior gamma radiation exposure.
While the compounds killed plenty of leukemia cells on their own, they worked even better when used after radiation therapy. Without radiation, CBD killed about 61% of cells, while the synthetic counterpart killed around 43% of leukemia cells. But, those numbers respectively rose to 93% and 95% for cells with previous radiation exposure.
What Symptoms of Leukemia Can Medical Marijuana Treat?
Medical marijuana helps ease the following cancer symptoms in patients:
· Lack of appetite
Oral cannabis provides anti-cancer effects and causes a decrease in leukemic blast cell count.