Besides skin cancer, prostate cancer is the most common cancer found in men, with a prevalence rate of almost 15% ("What are"). Moreover, 1 in 38 men will die of prostate cancer, as it is the second leading cause of cancer death in men. Although many types of prostate cancer are slow-growing, it is imperative for patients to take steps to manage or preferably kill the malignancy.
A 1999 study in FEBS Letters described the effects of THC on PC3 prostate cancer cells (Ruiz, Miguel, and Díaz-Laviada). THC was shown to dose-dependently reduce cell viability and induce apoptosis in PC3 cells through a CB1/CB2 receptor-independent mechanism. Activating both cannabinoid receptors with a synthetic agonist had no effect on cell viability, further reinforcing the receptor-independent nature of THC-induced cell death in PC3 cells. DNA fragmentation also occurred in a dose-dependent manner, consistent with apoptosis.